Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria

Protective Effect of Captopril against Doxorubicin-Induced Oxidative Stress in Isolated Rat Liver Mitochondria

      Doxorubicin (DOX) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. The dose-dependent cardiotoxicity of DOX significantly limits its anticancer efficacies. Oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to DOX mito...

Oxidative phosphorylation in mitochondria isolated from chronically stressed dog hearts.

Oxidative and phosphorylative activities were measured polarographically in mitochondria isolated from the right and left ventricles of normal and chronically stressed dog hearts. Chronic myocardial stress was produced experimentally by surgical procedures (combined tricuspid insufficiency and pulmonary stenosis, pulmonary insufficiency, aortic stenosis, aortic insufficiency, Potts's anastomosi...

Modelling of oxidative phosphorylation in isolated mitochondria and intact cells

Energetics and stoichiometry of oxidative phosphorylation from NADH to cytochrome c in isolated rat liver mitochondria.

The reaction 3-hydroxybutyrate (3-OH-butyrate) + 2 cytochrome c + ~ + 2 ADP + 2 Pi acetoacetate + 2 cytochrome e+’ + 2 ATP was used to study the energy relationships of electron transfer in the forward and reverse directions in suspensions of isolated rat liver mitochondria. Reduction of cytochrome c was monitored continuously at 550-540 nm while aliquots were taken to measure transmembrane pH ...

Streptolydigin, an inhibitor of oxidative phosphorylation in rat liver mitochondria.

Streptolydigin interferes with oxidative phosphorylation in rat liver mitochondria. The agent acts primarily as an uncoupler of respiration-associated phosphorylation but also impairs respiration to various degrees depending on the substrate. Streptolydigin partially inhibits electron flow at a point past the cytochrome b and prior to the cytochrome c reduction site. Streptolydigin also inhibit...